Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-04-08
1997-06-03
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 536 2431, 4353201, 435325, 4352523, 43525411, C12N 1512, C12N 510, C07K 1447
Patent
active
056353707
ABSTRACT:
A gene encoding mammalian brain enriched hyaluronan binding (BEHAB) protein is isolated and characterized from brain tissue and found to have a high degree of sequence homology to members of the proteoglycan tandem repeat family of hyaluronan binding proteins. Unlike other members of the family, however, the expression of the gene is restricted to the central nervous system. BEHAB is expressed in markedly increased levels in human glioma tissue, so that the polypeptide can be used as a marker for diagnostic purposes.
REFERENCES:
Stavrou, D., et al. (1989) Anticanc. Res. 9: 1489-96.
Yamada, H., et al. (01 Apr. 1994) J. Biol. Chem. 269: 10119-26.
Seidenbecher, I. C., et al. (27 Jun. 1994) GenBank database record, Acc. No. X79881.
Adams, M. D. et al., (30 Jun. 1993) GenBank database record, Acc. No. T04913.
Adams, M. D. et al., (1993) Nature Genetics 4: 256-67.
Jaworski, D. M., et al. (1995) J. Neurosci. 1352-62.
Hockfield Susan
Jaworski Diane M.
Fitzgerald David L.
Krinsky Mary M.
Yale University
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