DNA encoding aspartyl tRNA synthetase from Streptococcus pneumon

Details DNA encoding aspartyl tRNA synthetase from Streptococcus pneumon DNA encoding aspartyl tRNA synthetase from Streptococcus pneumon

1997-04-18

1998-05-05

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4353201, 4352523, 43525411, 435325, 536 232, C07H 2104, C12N 900, C12N 1500, C12N 120

Patent

active

057473153

ABSTRACT:
The invention provides aspS polypeptides and DNA (RNA) encoding aspS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aspS polypeptides to screen for antibacterial compounds.

REFERENCES:
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J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) pp. 322-324 (1980).
Eriani et al., "Aspartyl-tRNA Synthetase from Escherichia coli: Cloning and Characterisationof the Gene, Homologies of Its Translated Amino Acid Sequence with Asparaginyl-and Lysyl-tRNA Synthetases," Nucleic Acids Research, 18(23) pp. 7109-7117 (1990).
Poterszman et al., "Sequence, Overproduction and Crystallization of Aspartyl-tRNA Synthetase from Thermus thermophilus," FEBS Letters, 325(3) pp. 183-186 (1993).
Menguito et al., "Molecular Cloning, Sequence, Structural Analysis and Expression of the Histidyl-tRNA Synthetase Gene from Streptococcus equisimilis," Nucleic Acids Research, 21(3) pp. 615-620 (1993).
Von Den Haar et al., "Target Directed Drug Synthesis: The Aminoacyl-tRNA Synthetases as Possible Targets," Angewandte Chemie, 20(3) pp. 217-302 (1981).
Meinnel et al., "Aminoacyl-tRNA Synthetases: Ocurrence, Structure, and Function. IN: tRNA: Structure, Biosynthesis and Function," American Society of Microbiology, pp. 251-292 (1995).
Staudenbauer et al. (1972) Further Studies of the D-Aspartic Acid-activiating Enzyme of Streptococcus faecalis and Its Attachment to the Membrane. J. Biol. Chem. 247(17): 5289-5296.

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