DNA encoding anticoagulative protein PP4-X, and its preparation

Details DNA encoding anticoagulative protein PP4-X, and its preparation DNA encoding anticoagulative protein PP4-X, and its preparation

1992-12-04

1994-06-14

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530350, 514 2, 435 697, 4352402, 4353201, 536 234, 536 235, C12N 1512, C12N 1562, C12N 111

Patent

active

053209508

ABSTRACT:
The protein PP4-X, whose amino acid sequence and the DNA sequence coding for this have been determined, has anticoagulative properties and can be prepared by genetic manipulation. PP4-X is used for therapeutic and diagnostic purposes.

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patent: 4937324 (1990-04-01), Fujikawa et al.
Geisow, J. J. (1986) FEBS Lett. 203:99-103.
Creutz, C. E., et al. (1987) J. Biol. Chem. 262:1860-68.
Darnell, J. E., et al. (1986) Molecular Cell Biology, Sci. Am. Press, New York, p. 373.
Weber et al., "The Amino Acid Sequence of Protein II and its Phosphorylation Site for Protein Kinase C . . . " The EMBO Journal, 6:1599-1604, 1987.
Iwasaki et al., "Structure and Expression of cDNA for an Inhibitor of Blood Coagulation . . . ", J. Biochem. 102: 1261-1273 (1987).
Crumpton et al., "Protein Terminology Tangle", Nature, 345:212 (1990).

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