DNA encoding antibodies with altered effector functions

Details DNA encoding antibodies with altered effector functions DNA encoding antibodies with altered effector functions

1995-06-07

1997-07-15

Feisee, Lila

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 696, 4353201, 536 2353, C12N 1511, C12N 120

Patent

active

056482604

ABSTRACT:
The DNA encoding an antibody with an altered function, e.g. altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the Cl component of complement is produced by replacing the nucleic acid encoding at least one amino acid residue in the constant portion of the antibody with nucleic acid encoding a different residue.

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