DNA encoding and 18 KD CDK6 inhibiting protein

Details DNA encoding and 18 KD CDK6 inhibiting protein DNA encoding and 18 KD CDK6 inhibiting protein

1994-06-21

1997-05-20

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 435325, 435348, 435350, 435352, 435358, 435364, 435365, 435367, 536 235, C12N 121, C12N 510, C12N 1512, C12N 1563

Patent

active

056311567

ABSTRACT:
A nucleic acid encoding a CDK inhibiting protein, particularly a CDK6 inhibiting protein, is selected from the group consisting of: (a) DNA having the nucleotide sequence given herein as SEQ ID NO:1 (which encodes the protein having the amino acid sequence given herein as SEQ ID NO:2), and which are refered to as p18.sup.INK6 ; (b) nucleic acids which hybridize to DNA of (a) above and which encode a CDK inhibiting protein; and (c) nucleic acids which differs from the DNA of (a) or (b) above due to the degeneracy of the genetic code, and which encodes a CDK inhibiting protein encoded by a DNA of (a) or (b) above. Constructs containing such DNA, cells containing such constructs, proteins encoded by such DNA, antibodies which bind thereto, antisense oligonucleotides corresponding to such DNA, and methods of using the same are also disclosed.

REFERENCES:
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