Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1991-03-28
1994-09-06
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435 691, 4353201, 536 235, C12N 1512, C12N 1563
Patent
active
053447760
ABSTRACT:
The present invention pertains in general to invertebrate octopamine receptor proteins and to polynucleotides encoding such receptors. The present invention also relates to insect for example, Drosophila octopamine receptors that are recombinantly expressed in mammalian cells where the receptor mediates the attenuation of adenylate cyclase activity and exhibits a pharmacological profile that is unique but closely related to mammalian adrenergic receptors. The present invention further relates to drug screening methods for the development of specific human pharmacological drugs and insecticides targeted for the octopamine receptor system.
REFERENCES:
Arakawa et al. Cloning Localization and Permanent Expression of a Drosophila Octopamine Receptor Mar., 1990. Neuron vol. 2 pp. 343-354.
Saudou et al. Cloning and characterization of a Drosophila tyramine receptor Nov., 1990 EMBO vol. 9 (11) pp. 3611-3617.
Fraser Claire M.
McCombie William R.
Venter John C.
Hill Jr. Robert J.
The United States of America as represented by the Department of
Ulm John D.
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