DNA encoding an .alpha..sub.2B adrenergic receptor and uses ther

Details DNA encoding an .alpha..sub.2B adrenergic receptor and uses ther DNA encoding an .alpha..sub.2B adrenergic receptor and uses ther

1992-10-22

1997-01-21

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 6, 435 71, C12Q 100, C12Q 168

Patent

active

055958800

ABSTRACT:
The present invention provides an isolated nucleic acid molecule encoding an .alpha..sub.2B -adrenergic receptor, and an isolated protein which is a human .alpha..sub.2B -adrenergic receptor. The invention also provides vectors comprising DNA molecules encoding a human .alpha..sub.2B -adrenergic receptor, and vectors adapted for expression of the .alpha.2b.sub.2B -adrenergic receptor in bacterial, yeast, or mammalian cells. In addition, the invention provides a DNA probe useful for detecting nucleic acid encoding the .alpha.2b.sub.2B -adrenergic receptor, a method for determining whether a ligand which is not known to be capable of binding to the .alpha.2b.sub.2B -adrenergic receptor can bind to the .alpha..sub.2B -adrenergic receptor on the surface of a cell, and a method of screening drugs to identify drugs to identify drugs which specifically interact with, and bind to, the .alpha..sub.2B -adrenergic receptor. The invention herein also concern an antibody directed to the human .alpha..sub.2B -adrenergic receptor, such as a monoclonal antibody directed to an epitope of the .alpha..sub.2B -adrenergic receptor present on the surface of a cell and having an amino acid sequence included within the amino acid sequence shown in FIG. 2.

REFERENCES:
Bacchetti, S. et al. Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by . . . Proc. Natl. Acad. Sci. USA. (Apr. 1977) 74:1590-1594.
Regan, J. W. et al. Cloning and expression of a human kidney cDNA for an .alpha..sub.2 -adrenergic receptor subtype. Proc. Natl. Acad. Sci. USA. (Sep. 1988) 85:6301-6305.
Fraser et al. Biosis Abstract No. 85029825 J Biol Chem 262 (31) 1987. 14843-14846.
Kobilka et al. Embase Abstract No. 87225795 Science (USA) 1987, 238/4827, 650-656.
Regan et al. Biosis Abstract No. 86124412 Proc Natl Acad Sci USA 85(17) 1988. 6301-6305.

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