DNA encoding an .alpha..sub.2B -adrenergic receptor

Details DNA encoding an .alpha..sub.2B -adrenergic receptor DNA encoding an .alpha..sub.2B -adrenergic receptor

1989-10-30

1991-10-01

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4353201, 536 27, C12N 1512, C12N 510, C12N 1563

Patent

active

050533371

ABSTRACT:
The present invention provides an isolated nucleic acid molecule encoding an .alpha..sub.2B -adrenergic receptor, and an isolated protein which is a human .alpha..sub.2B -adrenergic receptor.
The invention also provides vectors comprising DNA molecules encoding a human .alpha..sub.2B -adrenergic receptor, and vectors adapted for expression of the .alpha..sub.2B -adrenergic receptor in bacterial, yeast, or mammalian cells.
In addition, the invention provides a DNA probe useful for detecting nucleic acid encoding the .alpha..sub.2B -adrenergic receptor, a method for determining whether a ligand which is not known to be capable of binding to the .alpha..sub.2B -adrenergic receptor can bind to the .alpha..sub.2B -adrenergic receptor, a method for detecting the presence of .alpha..sub.2B -adrenergic receptor on the surface of a cell, and a method of screening drugs to identify drugs which specifically interact with, and bind to, the .alpha..sub.2B -adrenergic receptor.
The invention herein also concerns an antibody directed to the human .alpha..sub.2B -adrenergic receptor, such as a monoclonal antibody directed to an epitope of the .alpha..sub.2B -adrenergic receptor present on the surface of a cell and having an amino acid sequence included within the amino acid sequence shown in FIG. 2.

REFERENCES:
Kobilka et al., "Coding Sequencing, and Expression of the Gene Coding for the Human Platelet .beta..sub.2 Adrenergic Receptor" Science vol. 238, pp. 650-656, (1987).

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