DNA encoding an 18 KD CDK6 inhibiting protein and antibodies the

Details DNA encoding an 18 KD CDK6 inhibiting protein and antibodies the DNA encoding an 18 KD CDK6 inhibiting protein and antibodies the

1995-06-07

1997-05-13

Knode, Marian C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303879, 5303877, 5303881, 53038822, C07K 1600

Patent

active

056294077

ABSTRACT:
A nucleic acid encoding a CDK inhibiting protein, particularly a CDK6 inhibiting protein, is selected from the group consisting of: (a) DNA having the nucleotide sequence given herein as SEQ ID NO:1 (which encodes the protein having the amino acid sequence given herein as SEQ ID NO:2), and which are refered to as p18.sup.INK6 ; (b) nucleic acids which hybridize to DNA of (a) above and which encode a CDK inhibiting protein; and (c) nucleic acids which differs from the DNA of (a) or (b) above due to the degeneracy of the genetic code, and which encodes a CDK inhibiting protein encoded by a DNA of (a) or (b) above. Constructs containing such DNA, cells containing such constructs, proteins encoded by such DNA, antibodies which bind thereto, antisense oligonucleotides corresponding to such DNA, and methods of using the same are also disclosed.

REFERENCES:
patent: 5302706 (1994-04-01), Smith
A. Kamb et al; A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types, Science 264, pp. 436-440 (1994).
Jean Marx; New Tumor Suppressor May Rival p53; Science 264, pp. 344-345 (1994).
Jean Marx; How p53 Suppresses Cell Growth; Science 262, pp. 1644-1645 (1993).
Hui Zhang et al; Proliferating Cell Nuclear Antigen and p21 Are Components of Multiple Cell Cycle Kinase Complexes; Molecular Biology of the Cell, 4, pp. 897-906 (1993).
Yue Xiong et al; p21 Is a Universal Inhibitor of Cyclin Kinases; Nature 366, pp. 701-704 (1993).
Yue Xiong et al; Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation; Genes & Development 7, pp. 1572-1583 (1993).
M. Serrano et al; A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4; Nature 366, pp. 704-707 (1993).
Yue Xiong et al; D Type Cyclins Associate with Multiple Protein Kinases and the DNA Replication and Repair Factor PCNA; Cell 71, pp. 505-514 (1992).

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