DNA encoding an 18 Kd CDK6 inhibiting protein

Details DNA encoding an 18 Kd CDK6 inhibiting protein DNA encoding an 18 Kd CDK6 inhibiting protein

1995-06-07

1997-04-15

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435194, 435 692, 435 6, 536 235, C07K 1447, C07H 2104, C12N 1512

Patent

active

056210825

ABSTRACT:
A nucleic acid encoding a CDK inhibiting protein, particularly a CDK6 inhibiting protein, is selected from the group consisting of: (a) DNA having the nucleotide sequence given herein as SEQ ID NO:1 (which encodes the protein having the amino acid sequence given herein as SEQ ID NO:2), and which are refered to as p18.sup.INK6 ; (b) nucleic acids which hybridize to DNA of (a) above and which encode a CDK inhibiting protein; and (c) nucleic acids which differs from the DNA of (a) or (b) above due to the degeneracy of the genetic code, and which encodes a CDK inhibiting protein encoded by a DNA of (a) or (b) above. Constructs containing such DNA, cells containing such constructs, proteins encoded by such DNA, antibodies which bind thereto, antisense oligonucleotides corresponding to such DNA, and methods of using the same are also disclosed.

REFERENCES:
patent: 5302706 (1994-04-01), Smith
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Yue Xiong et al; p21 Is a Universal Inhibitor of Cyclin Kinases; Nature 366, pp. 701-704 (1993).
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M. Serrano et al; A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4; Nature 366, pp. 704-707 (1993).
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Guan et al. "Growth suppression by p18, a p16(INK4/MTS1) and p14(INK 4B/MTS2)-related CDK6 inhibitor, correlates with wild-type pRb function" Gene & Development 8, 2939-2952.
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Hunter et al. "Cyclins and cancer II: cyclin D and CDK inhibitors come of age" Cell 79, 573-582.
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