DNA encoding an 18 Kd CDK6 inhibiting protein

Details DNA encoding an 18 Kd CDK6 inhibiting protein DNA encoding an 18 Kd CDK6 inhibiting protein

1995-06-07

1997-12-16

Elliott, George C.

Chemistry: molecular biology and microbiology

Vector, per se

536 231, 536 245, C12N 1563, C07H 2104

Patent

active

056984421

ABSTRACT:
A nucleic acid encoding a CDK inhibiting protein, particularly a CDK6 inhibiting protein, is selected from the group consisting of: (a) DNA having the nucleotide sequence given herein as SEQ ID NO:1 (which encodes the protein having the amino acid sequence given herein as SEQ ID NO:2), and which are refered to as p18.sup.INK6 ; (b) nucleic acids which hybridize to DNA of (a) above and which encode a CDK inhibiting protein; and (c) nucleic acids which differs from the DNA of (a) or (b) above due to the degeneracy of the genetic code, and which encodes a CDK inhibiting protein encoded by a DNA of (a) or (b) above. Constructs containing such DNA, cells containing such constructs, proteins encoded by such DNA, antibodies which bind thereto, antisense oligonucleotides corresponding to such DNA, and methods of using the same are also disclosed.

REFERENCES:
patent: 5302706 (1994-04-01), Smith
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Hui Zhang et al; Proliferating Cell Nuclear Antigen and p21 Are Components of Multiple Cell Cycle Kinase Complexes; Molecular Biology of the Cell, 4, pp. 897-906 (1993).
Xue Xiong et al; p21 Is a Universal Inhibitor of Cyclin Kinasesl; Nature; 366, pp. 701-704 (1993).
Xue Xiong et al; Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformations; Genes & Development 7, pp. 1572-1583 (1993).
M. Serrano et al; A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4; Nature 366, pp. 704-707 (1993).
Yue Xiong et al; D Type Cyclins Associate with Multiple Protein Kinases and the DNA Replication and Repair Factor PCNA; Cell 71, pp. 505-514 (1992).

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