Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-02-18
1998-11-03
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 712, 4351723, 435325, 4352523, 43525411, 4353201, 536 231, 536 235, 536 2351, 530324, 530326, 530327, 530328, 530329, 530399, 530402, C12N 1516, C12N 1563, C07K 1447
Patent
active
058307036
ABSTRACT:
According to the present invention, adrenomedullin which is a novel peptide having a hypotensive effect; proadrenomedullin N-terminal 20 peptide (proAM-N20) corresponding to an amino acid sequence of an N-terminus of proadrenomedullin, having a catecholamine secretion inhibitory effect; proadrenomedullin N-terminal 10-20 peptide (proAM-N(10-20)) having a Na channel inhibitory effect, and a gene encoding these peptides are provided. In addition, according to the present invention, these peptides in a sample containing adrenomdullin or proAM-N20 in an unknown amount can be quantified by using an antibody against adrenomedullin, proAM-N20, or its fragment.
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Eto Tanenao
Kangawa Kenji
Kitamura Kazuo
Matsuo Hisayuki
Haley, Jr. Esq. James F.
Kenji Kangawa
Mertz Prema
Shionogi & Co. Ltd.
Ulm John
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