DNA encoding a truncated pneumogoccal surface protein (PspA)

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352523, 43525233, 4352531, 4352534, 435849, 435885, 530416, 530417, 536 237, C12P 2102, C12N 121, C12N 1531, C07K 118

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059654007

ABSTRACT:
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.

REFERENCES:
patent: 4496538 (1985-01-01), Gordon
patent: 4673574 (1987-06-01), Anderson
Growth Characteristics of Group A Streptococci in a New Chemically Defined Medium, Rijn et al--Inf. and Imm. Feb. 1980, pp. 444-448.
McDaniel et al. 1989. Abstracts of the 89.sup.th annual meeting of the ASM, Abstract D-255.
Stover et al. Nature (351):456-60 Jun. 1991.
McDaniel et al (I), J.Exp.Med. 160:386-397, 1984.
McDaniel et al (II), Microbial Pathogenesis 1:519-531, 1986.
McDaniel et al (III), J.Exp.Med. 165:381-394, 1987.
McDaniel et al (IV), Infect. Immun., 59:222-228, 1991.
Crain et al, Infect.Immun., 58:3293-3299, 1990.
Abstracts of 89th Annual Meeting of the American Society for Microbiology, p. 125, item D-257, May 1989.
Abstracts of 90th Annual Meeting of the American Society for Microbiology, p. 98, item D-106, May 1990.
Abstracts of 3rd International ASM Conference on Streptococcal Genetics, p. 11, item 12, Jun. 1990.
Talkington et al, Infect. Immun. 59:1285-1289, 1991.
Yother et al, J. Bacteriol. 174:601-609, 1992.
Yother et al, J. Bacteriol. 174:610-618, 1992.
Bowie et al. Science 247:1306 1990.
Kumar et al PNAS 87:1337-1341 1990.
Sambrook et al. "Molecular Cloning, A Laboratory Manual" 1989 see Chapter 13.
Young and Davis PNAS 80:1194-98 Mar. 1983.

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