Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-03-28
1998-11-10
Walsh, Stephen
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 6, 4353201, 530350, 536235, 536243, C12N 1512, C12N 1563, C07K 14715
Patent
active
058342400
ABSTRACT:
The present invention provides a transforming growth factor-.beta. receptor associated protein (TGFAS) and polynucleotides which identify and encode TGFAS. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of TGFAS.
REFERENCES:
Attisano, L. et al., "TGF-.beta. receptors and actions", Biochim. Biophys. Acta, 1222: 71-80 (1994).
Leof, E.B. et al., "Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor .beta.: A proposed model for indirect mitogenesis involving autocrine activity", Proc. Natl. Acad. Sci., 83: 2453-2457 (1986).
Wrana, J.L. et al., "Mechanism of activation of the TGF-.beta. receptor", Nature, 370: 341-347 (1994).
Chen, R.H. et al., "A WD-domain protein that is associated with and phosphorylated by the type II TGF-.beta. receptor", Nature, 377: 548-552 (1995) (GI 1036804) (GI 1036805).
Bandman Olga
Lal Preeti
Bashan Daryl A.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Peterson Sheela-Mohan
Walsh Stephen
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