Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-04-21
1998-01-27
Walsh, Stephen G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 4352402, 4352523, 43525411, 4353201, C12N 1512
Patent
active
057123802
ABSTRACT:
The vascular endothelial cell growth factor (VEGF) inhibitors of the present invention are naturally occurring or recombinantly engineered soluble forms with or without a C-terminal transmembrane region of the receptor for VEGF, a very selective growth factor for endothelial cells. The soluble forms of the receptors will bind the growth factor with high affinity but do not result in signal transduction. These soluble forms of the receptor bind VEGF and inhibit its function.
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Kendall Richard L.
Thomas, Jr. Kenneth A.
Hand J. Mark
Merck & Co. , Inc.
Teng Sally P.
Tribble Jack L.
Walsh Stephen G.
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