Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1991-05-29
1993-08-17
Hill, Jr., Robert J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 4352401, 4353201, C12N 1512
Patent
active
052370569
ABSTRACT:
Described herein is the cloning and characterization of DNA encoding a protein which appears at an early stage in spinal cord development, is concentrated in motor neurons, and appears to have a role in neuromuscular junction formation. This protein copurifies with an activity which induces acetylocholine receptor synthesis in muscle fibers. A method for enhancing neurotransmitter receptor synthesis or accumulation in cells, especially that of the acetylcholine receptor, is also described.
REFERENCES:
Powels et al. from "Cloning Vectors" VIII-1 through 7, 1985.
Hunkapiller et al. Methods in Enzymology 91 pp. 227-236, 1983.
Suggs et al. Proc. Natl. Acad. Sci. USA 78(11) pp. 6613-6617, Nov. 1981.
"Purification and Characterization of a Polypeptide from Chick Brain that Promotes the Accumulation of Acetylcholine Receptors in Chick Myotubes", J. Cell. Biol. 103:493-507 (1986), Usdin, T. B. and Fischbach, G. D.
"Acetylcholine Receptor-Inducing Factor From Chicken Brain Increases the Level of mRNA Encoding the Receptor a Subunit", Proc. Natl. Acad. Sci. USA 85:1983-1987 (1988), Harris, D. A., et al.
Harris, D. A., et al., "Further Characterization of An Acetylcholine Receptor-Inducing Protein and Development of an Oligonucleotide Probe for this Molecule", Society for Neuroscience Abstracts (19th Annual Meeting, Phoenix, AZ, Oct. 29 to Nov. 3, 1989) 15 (Part 1):Abstract 70.6.
Falls, D. L., et al., "M.sub.r 42,000 ARIA:A Protein That May Regulate the Accumulation of Acetylcholine Receptors at Developing Chick Neuromuscular Junctions", Cold Spring Harbor Symposia on Quantitative Biology 55:397-406 (published Nov. 1991 according to Cold Spring Harbor Press).
Oesch, B. et al., "A Cellular Gene Encodes Scrapie PrP Protein", Cell 40:735-746 (1985).
Hill Jr. Robert J.
Ossanna Nina
President and Fellows of Harvard College
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