Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1990-06-10
1993-03-30
Lacey, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4353201, 43525233, 536 2351, 536 235, 530324, C07G 1512
Patent
active
051985420
ABSTRACT:
Disclosed are (1) a DNA containing a DNA segment coding for PACAP38; (2) a precursor protein of PACAP38; (3) a transformant containing a DNA having a DNA segment coding for PACAP38; (4) a method of preparing mature PACAP38 comprising cultivating the transformant described in the above (3), producing and accumulating a protein in a culture, and collecting the resulting protein; and (5) a method for preparing the above polypeptide comprising condensing a partial amino acid or a peptide which can constitute the mature PACAP38, with a residual portion, and removing a protective group if a product has the protective group. The DNA is applied to experimental animals to understand their brain functions, which serves to elucidate human brain functions. PACAP38 provides information about growth and maintenance of rat and human brain nerves, and can also be utilized as therapeutic agents for various neuropathy.
REFERENCES:
Tatsuno et al., Endocrinology 129(4):1797-1804 (1991).
Kimura et al., Biochem and Biophys Res Comm. 166(1): pp. 81-90(1990).
Miyata, et al., 71st Annual Meeting of the Endocrine Society, Seattle, Washington, Jun. 21-24, 1989. Abstract #168.
Arimura, et al., 71st Annual Meeting of the Endocrine Society, Seattle, Washington, Jun. 21-24, 1989. Abstract #964.
Arimura Akira
Kimura Chiharu
Kitada Chieko
Onda Haruo
Conlin David G.
Eisenstein Ronald I.
Guest Shelly J.
Lacey David
Takeda Chemical Industries, Inc.
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