DNA encoding a pituitary-specific thyroid hormone receptor

Details DNA encoding a pituitary-specific thyroid hormone receptor DNA encoding a pituitary-specific thyroid hormone receptor

1993-05-13

1994-02-08

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 641, 4353291, 536 235, C12N 1512

Patent

active

052849996

ABSTRACT:
The invention relates to the purification and cloning of a receptor for thyroid hormone. The receptor is designated PSTHR and is related to hormone receptors encoded by the genes erbA.alpha.-1, erbaA.alpha.-2 and erbA.beta.-1. The gene encoding PSTHR, erbA.beta.-2, is partially homologous to the erbA.beta.-1. However, PSTHR differs from the product of erbA.beta.-1 in that its expression is limited to the anterior pituitary gland. The invention additionally concerns the uses for PSTHR in the diagnosis and therapy of human conditions.

REFERENCES:
J. Biol. Chem. 259, 12084-12091, Oct. 10, 1984, Casanova et al. Photoaffinity Labeling of Thyroid Hormone Nuclear Receptors.
Science 2401889-895, May 13, 1988, Evans, The Steroid and Thyroid Hormone Receptor Superfamily.
Science 244:76-69, Apr. 7, 1984, Hodin et al. Identification of a Thyroid Hormone Receptor That is Pituitary Specific.
J. Biol. Chem. 262:3993-3994, Mar. 25, 1987, Mitsuhashi et al. n-Butyrate Increases the Level of Thyroid Hormone Nuclear Receptor in Non-Pituitary Cultured Cells.
Weinberger et al., Nature 324:641 (1986).
Sap et al., Nature 324:635-640 (1986).
Lazar et al., Mol. Endocrinol. 2:893-901 (1988).
Izumo et al., Nature 334:539-542 (1988).
Mistuhashi et al., PNAS 85:5804.varies.5808 (1988).
Koenig et al., PNAS 85:5034-5035 (1988).
Lazar et al., Mol. Endocrinolog, 2:479-484 (1988).
Benbrook et al., Science 238:788-791 (1987).
Kaji et al., Endocrinology 120(2):537-543 (1987).
Damm et al., Nature 339:593-597 (1989).
Koenig, R. J. et al., "Isolation of a cDNA Clone Encoding a Biologically Active Thyroid Hormone Receptor", Proc. Natl. Acad. Sci. U.S.A. 85:5031-5035 (1988).
Thompson, C. C. et al., "Identification of a Novel Thyroid Hormone Receptor Expressed In The Mammalian Central Nervous System", Science 237:1610-1614 (1987).

Affiliated with

Also associated with

Rating

DNA encoding a pituitary-specific thyroid hormone receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA encoding a pituitary-specific thyroid hormone receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding a pituitary-specific thyroid hormone receptor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-699346