DNA encoding a novel penicillin binding protein from streptococc

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 435325, 536 237, C07H 2104, C12N 1500, C12N 1509

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active

057892024

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.

REFERENCES:
Dowson, et al., Molecular Microbiology, (1989) 3(1), 95-102.
Laible, et al., Molecular Microbiology, (1989) 3(10), 1337-1348.
Liable, et al., Molecular Microbiology, (1991) 5(8), 1993-2002.
Martin, et al. Journal of Bacteriology, Jul. 1992, pp. 4517-4523.
Schuster, et al., Journal of Bacteriology, Nov. 1990, pp. 6499-6505.

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