DNA encoding a novel mammalian transporter homologous to neurotr

Details DNA encoding a novel mammalian transporter homologous to neurotr DNA encoding a novel mammalian transporter homologous to neurotr

1993-11-09

1996-09-24

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352523, 4352542, 4353201, 536 235, C12N 506, C12N 121, C12N 119, C12N 1563

Patent

active

055590217

ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a mammalian rB21a transporter, an isolated protein which is a mammalian rB21a transporter, vectors comprising an isolated nucleic acid molecule encoding a mammalian rB21a transporter, mammalian cells comprising such vectors, antibodies directed to the mammalian rB21a transporter, nucleic acid probes useful for detecting a nucleic acid molecule encoding mammalian rB21a transporter, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a mammalian rB21a transporter, pharmaceutical compounds related to mammalian rB21a transporter, and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian rB21a transporter. This invention further provides methods for determining substrate binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with the mammalian rB21a transporter.

REFERENCES:
Smith, K. E. et al. (1993) "Cloning of a rat brain cDNA encoding a novel `orphan` transporter" Soc. Neurosci: Abstr. 19(1):747.

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