DNA encoding a neuronal cell-specific receptor protein

Details DNA encoding a neuronal cell-specific receptor protein DNA encoding a neuronal cell-specific receptor protein

1996-10-25

2000-10-17

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435325, 4353201, 4352521, 536 231, 536 235, C12N 1512, C12N 1563, C12N 1585

Patent

active

061329886

ABSTRACT:
To provide a method of isolating and detecting a new receptor gene, as a means of elucidating the function of neuronal cell-specific receptors, especially of elucidating the detailed mechanism of the neuronal cell differentiation inhibitory and nerve nutrition factor-like actions of activin receptors, DNA containing said new receptor gene, a method of producing a protein encoded by this new receptor gene, and use for this DNA and protein. The receptor protein of the present invention and DNA encoding this protein can be used for various purposes, including 1) ligand determination, 2) obtainment of antibodies and antisera, 3) construction of recombinant receptor protein expression systems, 4) development of receptor binding assay systems and screening for pharmaceutical candidate compounds using expression systems, 5) drug designing based on comparison with structurally similar ligand receptors, 6) reagent for preparation of probes and PCR primers for gene diagnosis, and 7) drug for gene therapy.

REFERENCES:
J. Xu et al., "Inhibin Antagonizes Inhibition of Liver Cell Growth by Activin by a Dominant-negative Mechanism," J. Biol. Chem. 270:6308-6313 (1995).
Matthews, et al., "Expression Cloning of an Activin Receptor, A predicted Transmembrane Serine Kinase", Cell 65:973-982 (1991).

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