DNA encoding a Myt1 polypeptide

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

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435243, 4353201, 4352542, 435410, 536 235, 536 2431, 536 2433, C12N 510, C12N 100, C12N 116, C12N 1511

Patent

active

060201940

ABSTRACT:
The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.

REFERENCES:
Okamoto et al, Mol. Gen. Genet., vol. 243, No. 4: pp. 473-476, May 25, 1994 .

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