DNA encoding a limbic system-associated membrane protein

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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536 231, 536 2351, 536 241, 4353201, 4352523, 435325, C12N 1518, C12N 1563, C12N 1585, C07H 2104

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058612831

ABSTRACT:
The present invention is directed to nucleic acid sequences encoding a limbic-system associated membrane protein ("LAMP") and to purified proteins with LAMP activity. LAMP is a self-binding, antibody-like cell surface adhesion protein, the presence of which on one neuron of the limbic system stimulates the formation of connections with adjacent neurons. The invention provides a nucleic acid sequence encoding a polypeptide with at least about 90% homology to a LAMP self-binding domain, and corresponding proteins. The invention also provides nucleic acids that hybridize to LAMP encoding nucleic acids.

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