Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-03-10
1996-12-24
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 536 235, C12N 510, C12N 1512
Patent
active
055873014
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode the hyaluronan receptor (hr) from human umbilical vein endothelial cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode hr, expression vectors for the production of purified HR, antibodies capable of binding specifically to HR, hybridization probes or oligonucleotides for the detecting the upregulation of HR encoding nucleotide sequences, genetically engineered host cells for the expression of HR, diagnostic tests for activated, angiogenic, inflamed or metastatic cells and/or tissues based on HR-encoding nucleic acid molecules and antibodies capable of binding specifically to the receptor.
REFERENCES:
Hardwick et al., J. Cell Biol. 117: 1343-1350, 1992.
Cheryl B. Knudson and Warren Knudson, "Hyaluronan-binding proteins in development, tissue homeostasis, and disease", The FASEB Journal, Copyright 1993, vol. 7, pp. 1233-1241.
Orvard C. Laurent and J. Robert E. Fraser, "Hyaluronan", The FASEB Journal, Copyright 1992, vol. 6, pp. 2397-2404.
P. Ghosh, "The role of hyaluronic acid (hyaluronan) in health and disease: interactions with cells, cartilage and components of synovial fluid", Clinical and Experimeantly Pheumatology 12; Copyright 1994, pp. 75-82.
Hawkins Phillip R.
Seilhamer Jeffrey J.
Wilde Craig G.
Incyte Pharmaceuticals Inc.
Luther Barbara J.
Ulm John
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