DNA encoding a human thrombomodulin having a modified glycosamin

Details DNA encoding a human thrombomodulin having a modified glycosamin DNA encoding a human thrombomodulin having a modified glycosamin

1993-08-23

1994-10-11

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530381, 536 231, 536 235, 4353201, 4352402, C12N 1515, C12N 510

Patent

active

053546644

ABSTRACT:
Thrombin-binding substances capable of promoting anti-thrombin III activity and inhibiting platelet aggregation, and by themselves possessing anti-thrombin activity are disclosed. The thrombin-binding substances are useful as an effective component of anticoagulant agents, and can be produced inexpensively on a large scale.

REFERENCES:
Jackman, R. W., et al. (1987) Proc. Natl. Acad. Sci. USA 84: 6425-6429.
Parkinson, J. F., et al. (1990) Biochem. Biophys. Res. Comm. 169(1): 177-83.
Nawa, K., et al. (1990) id. 171(2): 729-37.
Bourdon, M. A., et al. (1986) J. Biol. Chem. 261(27): 12534-37.

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