DNA encoding a human serotonin receptor (5-HT.sub.4B) and uses t

Details DNA encoding a human serotonin receptor (5-HT.sub.4B) and uses t DNA encoding a human serotonin receptor (5-HT.sub.4B) and uses t

1994-07-27

2000-07-04

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Rodent cell, per se

536 235, 435 691, 4353201, 435325, 435354, C12N 1512

Patent

active

060837497

ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT.sub.4B receptor and an isolated nucleic acid molecule encoding a human 5-HT.sub.4B receptor, an isolated protein which is a mammalian 5-HT.sub.4B receptor, an isolated protein which is a human 5-HT.sub.4B receptor, vectors comprising an isolated nucleic acid molecule encoding a mammalian 5-HT.sub.4B receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT.sub.4B receptor, mammalian cells comprising such vectors, antibodies directed to the 5-HT.sub.4B receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian or human 5-HT.sub.4B receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian or human 5-HT.sub.4B receptor, pharmaceutical compounds related to the human 5-HT.sub.4B receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian or human 5-HT.sub.4B receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with a human 5-HT.sub.4B receptor.

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