Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-11-30
1997-08-26
Brittingham, Debra
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352351, 435325, 435357, 435361, 435367, 536 235, 935 70, C12N 500, C12N 700, C12N 1500, C07H 2102
Patent
active
056610246
ABSTRACT:
The present invention provides an isolated nucleic acid molecule encoding an 5-HT.sub.2 receptor, and an isolated protein which is a human 5-HT.sub.2 receptor.
The invention also provides vectors comprising DNA molecules encoding a human 5-HT.sub.2 receptor, and vectors adapted for expression of the 5-HT.sub.2 receptor in bacterial, yeast, or mammalian cells.
In addition, the invention provides a DNA probe useful for detecting nucleic acid encoding the 5-HT.sub.2 receptor, a method for determining whether a ligand which is not known to be capable of binding to the 5-HT.sub.2 receptor can bind to the 5-HT.sub.2 receptor, a method for detecting the presence of 5-HT.sub.2 receptor on the surface of a cell, and a method of screening drugs to identify drugs which specifically interact with, and bind to, the 5-HT.sub.2 receptor.
The invention herein also concerns an antibody directed to the human 5-HT.sub.2 receptor, such as a monoclonal antibody directed to an epitope of the 5-HT.sub.2 receptor present on the surface of a cell and having an amino acid sequence included within the amino acid sequence shown in FIG. 2.
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Branchek Theresa
Hartig Paul R.
Kao Hung-Teh
Brittingham Debra
Synaptic Pharmaceutical Corporation
White John P.
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