Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-02-03
1996-08-13
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 691, 435 703, 435 712, 4353201, 536 231, 536 235, C07H 2104, C12N 510, C12N 1512, C12N 1563
Patent
active
055455492
ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a human Y2 receptor, an isolated protein which is a human Y2 receptor, vectors comprising an isolated nucleic acid molecule encoding a human Y2 receptors, mammalian cells comprising such vectors, antibodies directed to the human Y2 receptor, nucleic acid probes useful for detecting nucleic acid encoding human Y2 receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human Y2 receptor, pharmaceutical compounds related to human Y2 receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human Y2 receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human Y2 receptor.
REFERENCES:
Wahlestedt, C., et al. Neuropeptide Y Receptor Subtypes, Y1 and Y2. Ann. N. Y. Acad. Sci. 1990; 611:7-26 (Exhibit B).
Wahlestedt, C., et al. Indentification of Cultured Cells Selectively Expressing Y1-, Y2-, Or Y3-Type Receptors for Neuropeptide Y/Peptide YY. Life Sciences 1991; 50(4): PL-7 -PL-12 (Exhibit C).
Sheikh, S. P., et al. Binding of Monoiodinated Neuropeptide Y to Hippocampal Membranes and Human Neuroblastoma Cell Lines. J. Biol. Chem. 1989; 264(12):6648-6654 (Exhibit D).
Larhammar, D., et al. Cloning and Functional Expression of a Human Neuropeptide Y/Peptide YY Receptor of the Y1 Type. J. Biol. Chem. 1992; 267(16):10935-10938 (Exhibit E).
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Branchek Theresa
Gerald Christophe
Walker Mary W.
Weinshank Richard L.
Gucker Stephen
Synaptic Pharmaceutical Corporation
Walsh Stephen G.
White John P.
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