Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-12-28
1996-05-14
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352401, 4352402, 4352523, 43525411, 4353201, 536 231, C12N 1509, C07H 2100, C12P 2102
Patent
active
055166539
ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a human Y4 receptor, an isolated protein which is a human Y4 receptor, vectors comprising an isolated nucleic acid molecule encoding a human Y4 receptors, mammalian cells comprising such vectors, antibodies directed to the human Y4 receptor, nucleic acid probes useful for detecting nucleic acid encoding human Y4 receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human Y4 receptor, pharmaceutical compounds related to human Y4 receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human Y4 receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human Y4 receptor.
REFERENCES:
patent: 4839343 (1993-06-01), Waeber et al.
Larhammar et al., The J. of Biol. Chem., vol. 267, pp. 10935, 1992.
Wahlestedt et al., Ann. N.Y. Acad. Sci, vol. 611, pp. 7, 1990.
Whitcomb, D. C., et al. Am. J. Physiol. 1990; 259:G687-G691 (Exhibit B).
Herbert Herzog, et al. PNAS 1992; 89:5794-5798 (Exhibit D).
Claes Wahlestedt, et al. Life Sciences 1991; 50:PL7-PL12 (Ehibit E).
Jan M. Lungberb, et al. The Journal of Neuroscience 1984; 4:(9):2376-2386 (Exhibit F).
Bard Jonathan A.
Branchek Theresa
Walker Mary W.
Weinshank Richard L.
Draper Garnette D.
Synaptic Pharmaceutical Corporation
Teng Sally P.
White John P.
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