DNA encoding a human membrane protein

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 6, 4353201, 435325, 530350, 536 235, 536 2431, C12N 1512, C12N 1564, G01N 3358, C07K 14435

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058637648

ABSTRACT:
The present invention provides a human membrane protein (NHMP1) and polynucleotides which identify and encode NHMP1. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHMP1 and a method for producing NHMP1. The invention also provides for agonists, antibodies, or antagonists specifically binding NHMP1, and their use, in the prevention and treatment of diseases associated with expression of NHMP1. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHMP1 for the treatment of diseases associated with the expression of NHMP1. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHMP1.

REFERENCES:
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Hillier, et al. EST-STS-TWO, The WashU-Merck Est Project, Accession No.: N62956, Mar. 6, 1996.
Unwin, N., et al., "The Structure of Proteins in Biological Membranes," Sci. Am., 250:78-87 (1984).
Borsting, C., et al. (GI 1620453) GenBank Sequence Database (Accession Y08687) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
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Hajnal, A., et al., "Subtraction cloning of H-rev107, a gene specifically expressed in H-ras resistant fibroblasts," Oncognen, 9(2):479-490 (1994).

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