Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-06-10
2008-06-10
Ulm, John (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007210, C436S501000
Reexamination Certificate
active
07384752
ABSTRACT:
A cDNA encoding a human imidazoline receptor is described. The amino acid sequence of the entire imidazoline receptor protein is identified, as well as a C-terminal fragment believed to contain the imidazoline binding site of the receptor. The protein is highly unique in its sequence and may represent the first in a novel family of receptor proteins. Methods of cloning the cDNA and expressing the imidazoline receptor in a host cell are described. Also, a screening method for identifying drugs that interact with the imidazoline receptor is described.
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J. Piletz, et al., Nonadrenergic Imidazoline Binding Sites on Human Platelets, The Journal of Pharmacology and Experimental Therapeutics, vol. 267, No. 3, pp. 1493-1502, 1993.
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H. Wang, et al., “Isolation and Characterization of Imidazoline Receptor Protien from Bovine Adrenal Chromaffin Cells”, The Journal of Pharmacology and Experimental Therapeutics, vol. 42, pp. 792-801, 1992.
H. Wang, et al., “Production and Characterization of Antibodies Specific for the Imidazoline Receptor Protein”, The Journal of Pharmacology and Experimental Therapeutics, vol. 43, pp. 509-515, 1993.
P. Ernsberger, et al., “I1-Imidazoline Receptors Definition, Characterization, and Transmembrane Signaling”, Annals New York Academy of Sciences, vol. 763, pp. 22-42, 1995.
Fourth IBRO World Congress Neuroscience. Abstract G2.29, Piletz, et al., “Platelet α2and 11-Imdizoline Binding Sites in Depression” Kyoto, Japan, Jul. 9-14, 1995.
J. Piletz, et al., “Imidazoline Receptors in Depression”, American College of Neuropsychopharmacology 34thAnnual Meeting, p. 119, 1995.
A. Parini, et al., The Elusive Family of Imidazoline Binding Sites, TiPS, vol. 17, pp. 13-16, 1996.
J. Piletz, et al., Desipramine Lowers Tritiated Para-Aminoclonidine Binding in Platelets of Depressed Patients, Arch Gen Psychiatry, vol. 408, pp. 813-820, 1991.
J. Piletz, et al., “Psychopharmacology of Imidazoline and α2-Adrenergic Recpetors: Implications for Depression”, Critical Reviews in Neurobiology, vol. 9, No. 1, pp. 26-66, 1994.
ESTO4033, in : Adams, et al., Nature Genet, 4, pp. 256-267.
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P. Ernsberger et al., “Role of Imidazole Receptors in the Vasodepressor Response to Clonidine Analogs in the Rostral Ventrolateral Medulla1”, The Journal of Pharmacology and Experimental Therapeutics, vol. 253, No. 1, pp. 408-418, (1990).
J. Piletz et al., “Nonadrenergic Imidazoline Binding Sites on Human Platelets”, The Journal of Pharmacology and Experimental Therapeutics, vol. 267, No. 3, pp. 1493-1502, (1993).
B. Lanier et al., “Structural and Ligand Recognition Properties of Imidazoline Binding Proteins in Tissues of Rat and Rabbit”, The American Society for Pharmacology and Experimental Therapeutics, vol. 48, pp. 703-710, (1995).
F. Bennai et al., “Antiidiotypic Antibodies as Tools to Study Imidazoline Receptors”, Annals New York Academy of Sciences, vol. 763, pp. 140-148, (1995).
H. Wang et al., “Isolation and Characterization of Imidazoline Receptor Protein from Bovine Adrenal Chromaffin Cells”, The American Society for Pharmacology and Experimental Therapeutics, vol. 42, pp. 792-801, ((1992).
H. Wang et al., “Production and Characterization of Antibodies Specific for the Imidazoline Receptor Protein”, The American Society for Pharmacology and Experimental Therapeutics, vol. 43, pp. 509-515, (1993).
P. Ernsberger et al., “I1-Imidazoline Receptors Definition, Characterization, Distribution, and Transmembrane Signaling”, Annals New York Academy of Sciences, vol. 763, pp. 22-42, (1995).
Fourth IBRO World Congress of Neuroscience. Abstract G2.29, Piletz et al. Platelet α1- and 11-Imidizoline Binding Sites in Depression, Kyoto, Japan, Jul. 9-14, (1995).
J. Piletz et al., “Imidazoline Receptors in Depression”, American College of Neuropsychopharmacology, 34th Annual Meeting, Poster Session 1, p. 119, (1995).
A. Parini et al., “The Elusive Family of Imidazoline Binding Sites”, TiPS, vol. 17, pp. 13-16, (1996).
J. Piletz et al., “Desipramine Lowers Tritiated Para-Aminoclonidine Binding in Platelets of Depressed Patients”, Arch Gen Psychiatry, vol. 48, pp. 813-820, (1991).
J. Piletz et al., “Psychopharmacology of Imidazoline and α2-Adrenergic Receptors: Implications for Depression”, Critical Reviews in Neurobiology, vol. 9, No. 1, pp. 29-66, (1994).
Adams et al., ESTO4033Homo sapienscDNA, locus TO6144, Jun. 30, 1993.
Wang et al., Molecular Pharmacology 43 (4) 509-515, Apr. 1993.
Lin et al., Science 190:61-63, Oct. 1975.
Ivanov Tina R.
Piletz John E.
Myers, Jr. Richard S.
Stites & Harbison PLLC
Ulm John
University of Mississippi Medical Center
Weyer Stephen
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