Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1995-10-17
1998-01-27
Wax, Robert A.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
43525411, 4353201, 536 235, C12N 500, C12N 114, C12N 1500, C07H 2104
Patent
active
057121486
ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a mammalian betaine/GABA transporter, an isolated nucleic acid molecule encoding a human betaine/GABA transporter, an isolated protein which is a mammalian betaine/GABA transporter, an isolated protein which is a human betaine/GABA transporter, vectors comprising an isolated nucleic acid molecule encoding a mammalian betaine/GABA transporter, vectors comprising an isolated nucleic acid molecule encoding a human betaine/GABA transporter, mammalian cells comprising such vectors, antibodies directed to the mammalian betaine/GABA transporter and antibodies directed to the human betaine/GABA transporter, nucleic acid probes useful for detecting nucleic acid molecules encoding mammalian betaine/GABA transporters and human betaine/GABA transporters, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian betaine/GABA transporter or a human betaine/GABA transporter, pharmaceutical compounds related to mammalian and human betaine/GABA transporters, and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian or human betaine/GABA transporter. This invention further provides methods for determining substrate binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with mammalian betaine/GABA transporters and human betaine/GABA transporters.
REFERENCES:
patent: 5081227 (1992-01-01), Millan
Yamauchi, et al. (1992) J. Biol. Chem. 267:649-652.
Giros, et al. (1991) FEBS Letters 295:149-154.
Robey, et al. (1991) J. Biol. Chem. 266:10400-10405.
Pachelczyk, et al. (1991) Nature 350:350-354.
Blakely, et al. (1991) Anal. Biochem. 194:302-308.
Miller and Germain (1986) J. Exp. Med. 164:1478-1489.
Miller et al. (1986) J. Exp. Med. 164, 1478-1489.
Robey et al. (1991) J. Biol. Chem 266, 10400-10405.
ATCC Catalogue of Cell Lines and Hybridomas 6th Ed., pp. 2-3.
Borden et al. (1995) J. Neurochem. 64: 977-984.
Lopez-Corcuera, B., et al., Expression of a Mouse Brain cDNA Encoding Novel .gamma.-Amino-butyric Acid Transporter, J. Biol. Chem. 1992, 267(25):17491-17493.
Borden Laurence A.
Smith Kelli E.
Weinshank Richard L.
Hobbs Lisa J.
Synaptic Pharmaceutical Corporation
Wax Robert A.
White John P.
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