DNA encoding a fusion protein comprising a viral antigen and lym

Details DNA encoding a fusion protein comprising a viral antigen and lym DNA encoding a fusion protein comprising a viral antigen and lym

1996-02-13

1998-03-17

Walsh, Stephen

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 234, 435 697, 4352523, 435 6952, 530351, 530403, C12N 1526, C12N 1533, C12N 1562, C12N 121

Patent

active

057285527

ABSTRACT:
Disclosed are (1) a fused protein obtained by combining an antigen used for vaccine and a lymphokine by the application of gene engineering, (2) a recombinant DNA containing a nucleotide sequence coding for the above fused protein, (3) a transformant bearing the above recombinant DNA, (4) a method for producing the fused protein which comprises cultivating the above transformant, producing and accumulating the above fused protein in a culture, and collecting the fused protein, and (5) a hybrid protein obtained by chemically combining an antigen used for vaccine with a lymphokine. The resulting fused and hybrid proteins have strong immunogenicity.

REFERENCES:
patent: 4761375 (1988-08-01), Clark
patent: 5273876 (1993-12-01), Hock et al.
patent: 5556946 (1996-09-01), Fujisawa et al.
Weinberg et al., Journal of Immunology, 140:1, pp. 294-299 (1988).
R. Seno et al., FEBS, 199:2, pp. 187-192 (1986).

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