DNA encoding a chemokine, Beta R1, comprising the Beta R1 promot

Details DNA encoding a chemokine, Beta R1, comprising the Beta R1 promot DNA encoding a chemokine, Beta R1, comprising the Beta R1 promot

1997-09-11

1999-11-02

Fitzgerald, David L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 241, 435 695, 4353201, C12N 1519, C07K 1452

Patent

active

059773340

ABSTRACT:
The invention provides a chemokine designated Beta R1, whose production in T cells, astrocytes, a fibroblasts is preferentially induced by IFN-.beta. as compared to IFN-.alpha.. A cDNA encoding the Beta R1 polypeptide and comprising the endogenous Beta R1 promoter is described. When coupled to a reporter gene, the promoter sequence may be used to screen for mimics of IFN-.beta. activity.

REFERENCES:
patent: 5707829 (1998-01-01), Jacobs et al.
"Characterization of .beta.-R1, a Gene that is Selectively Induced by Interferon .beta. (IFN-.beta.) compared with IFN-.alpha.*", Rani, et al., The Journal of Biological Chemistry; vol. 271, No. 37, Sep. 13, 1996; pp. 22878-22884.
GenBank Accession, U59286; Oct. 24, 1996.

Affiliated with

Also associated with

Rating

DNA encoding a chemokine, Beta R1, comprising the Beta R1 promot does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA encoding a chemokine, Beta R1, comprising the Beta R1 promot, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding a chemokine, Beta R1, comprising the Beta R1 promot will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2137114