Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-03-18
2000-03-28
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 436 94, 436173, 536 253, 536 254, C12Q 168, C12P 1934
Patent
active
060430311
ABSTRACT:
The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.
REFERENCES:
patent: 4214159 (1980-01-01), Hillenkamp et al.
patent: 4442354 (1984-04-01), Hurst et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4725677 (1988-02-01), Koster et al.
patent: 4778993 (1988-10-01), Waugh
patent: 4920264 (1990-04-01), Becker
patent: 5003059 (1991-03-01), Brennan
patent: 5045694 (1991-09-01), Beavis et al.
patent: 5062935 (1991-11-01), Schlag et al.
patent: 5064754 (1991-11-01), Mills
patent: 5118605 (1992-06-01), Urdea
patent: 5118937 (1992-06-01), Hillenkamp et al.
patent: 5135870 (1992-08-01), Williams
patent: 5149625 (1992-09-01), Church et al.
patent: 5202561 (1993-04-01), Giessmann et al.
patent: 5210412 (1993-05-01), Levis et al.
patent: 5237016 (1993-08-01), Ghosh et al.
patent: 5288644 (1994-02-01), Beavis et al.
patent: 5373156 (1994-12-01), Franzen
patent: 5376788 (1994-12-01), Standing et al.
patent: 5380833 (1995-01-01), Urdea et al.
patent: 5381008 (1995-01-01), Tanner et al.
patent: 5382793 (1995-01-01), Weinberger et al.
patent: 5436327 (1995-07-01), Southern et al.
patent: 5474895 (1995-12-01), Ishii et al.
patent: 5478893 (1995-12-01), Ghosh et al.
patent: 5503980 (1996-04-01), Cantor
patent: 5510613 (1996-04-01), Reilly et al.
patent: 5547835 (1996-08-01), Koster
patent: 5580733 (1996-12-01), Levis et al.
patent: 5605798 (1997-02-01), Koster
patent: 5622824 (1997-04-01), Koster
patent: 5624711 (1997-04-01), Sundberg et al.
patent: 5625184 (1997-04-01), Vestal et al.
patent: 5627369 (1997-05-01), Vestal et al.
patent: 5631134 (1997-05-01), Cantor
patent: 5641959 (1997-06-01), Holle et al.
patent: 5643798 (1997-07-01), Beavis et al.
patent: 5654545 (1997-08-01), Holle et al.
patent: 5663242 (1997-09-01), Ghosh et al.
patent: 5691141 (1997-11-01), Koster
patent: 5700642 (1997-12-01), Monforte et al.
patent: 5742049 (1998-04-01), Holle et al.
patent: 5760393 (1998-06-01), Vestal et al.
patent: 5777324 (1998-07-01), Hillenkamp
patent: 5777325 (1998-07-01), Weinberger et al.
patent: 5795714 (1998-08-01), Cantor et al.
patent: 5830655 (1998-11-01), Monforte et al.
patent: 5846710 (1998-12-01), Bajaj
patent: 5864137 (1999-06-01), Becker et al.
patent: 5869242 (1999-02-01), Kamb
patent: 5885775 (1999-03-01), Haff et al.
Landegren et al., Science 241, 1077-1080, 1988.
Lopez-Galindez et al., Proc. Natl. Acad. Sci. USA 88, 4280-4284, 1991.
Kuppuswamy et al., Proc. Natl. Acad. Sci. USA 88, 1143-1147, 1991.
Sokolov, Nucleic Acids Res. 18(12), 3671, 1990.
Wu et al., Proc. Natl. Acad. Sci. USA 86, 2757-2760, 1989.
Light-Wahl et al., J. Am. Chem. Soc. 115, 804-805, 1993.
Chen et al., "Laser mass spectrometry for DNA fingerprinting for forensic applications", Annual Meeting of the Society of Photo Optical Instrumentation Engineers , Jul. 24-29, 1994.
Jacobson et al., "Applications of mass spectrometry to DNA fingerprinting and DNA sequencing", International Symposium on the Forensic Aspects of DNA Analysis , Mar. 29-Apr. 2, 1993 (Abstract).
Liu et al., "Use of Nitrocellulose Film Substrate in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry for DNA Mapping and Screening", Anal. Chem., 67:3482-3490 (1995).
Andersen, et al., Electrospray ionization and matrix assisted laser desorption/ionization mass spectrometry: Powerful analytical tools in recombinant protein chemistry, Nature Biotech. 14: 449-457 (1996).
Ardey, Electrospray mass spectrometry, Spectroscopy Europe, 4:10-20 (1992).
Arlinghaus et al., "Applications of resonance ionization spectroscopy for semiconductor, environmental and biomedical analysis, and for DNA sequencing", SPIE, vol. 1435, Opt. Methods Ultrasensitive Detect. Anal. Tech. Appl. pp. 26-35 (1991).
Beck et al., Applications of dioxetane chemiluminescent probes to molecular biology, Anal. Chem. 62:2258-2270 (1990).
Beck et al., Chemiluminescent detection of DNA: application for DNA sequencing and hybridization, Nucl Acids Res 17:5115-5123 (1989).
Berkenkamp et al., Infrared MALDI mass spectrometry of large nucleic acids, Science 281:260-2 (1998).
Braun et al., Detecting CFTR gene mutations by using primer oligo base extension and mass spectrometry, Clinical Chemistry 43:1151-1158 (1997).
Braun et al., Improved Analysis of Microsatellites Using Mass Spectrometry, Genomics 46:18-23(1997).
Broude et al., Enhanced DNA sequencing by hybridization, Proc. Natl. Acad. Sci. USA 91:3072-3076 (1994).
Caldwell et al., Mid-infrared matrix assisted laser desorption ionization with a water/glycerol matrix, Applied Surface Science 127-129 :242-247(1998).
Covey, et al., The determination of protein, oligonucleotide and peptide molecular weights by ion-spray mass spectrometry, Rapid Comm. Mass Spectrom. 2:249-256 (1988).
Crain, Mass spectrometric techniques in nucleic acid research, Mass Spectrom. Rev. 9:505-554 (1990).
Eckstein (ed.), Oligonucleotides and Analogues, IRL Press, Oxford (1991).
Edmonds et al., Thermospray liquid chromatographny-mass spectrometry of nucleosides and of enzymatic hydrolysates of nucleic acids, Nucleic Acids Research 13:8197-8206 (1985).
Ehring et al., Photochemical versus thermal mechanisms in matrix-assisted laser desorption/ionization probed by back side desorption, Rapid Comm in Mass Spect 10:821-824 (1996).
Frank et al., DNA chain length markers and the influence of base composition on electrophoretic mobility of oligodeoxyribonucleotides in polyacrylamide-gels, Nucl Acids Res 6:2069-2087.
Fu et al., A DNA sequencing strategy that requires only five bases of known terminal sequenec for priming, Proc. Natl. Acad. Sci. USA 92:10162-10166 (1995).
Fu et al., A DNA sequencing strategy which requires only five bases of known terminal sequence for priming, Paper presented, Genome Mappping and Sequencing, Cold Spring Harbor Laboratory.
Fu et al., Efficient preparation of short DNA sequence ladders potentially suitable for MALDI-TOF DNA sequencing, Genetic Analysis 12:137-142 (1996).
Fu et al., Sequencing double-stranded DNA by strand displacement, Nucl Acids Res 25:677-679 (1997).
Fu et al., Sequencing exons 5 to 8 of the p53 gene by MALDI-TOF mass spectrometry, Nat Biotechnol 16:381-4 (1998).
Gross et al., Investigations of the metastable decay of DNA under ultraviolet matrix-assisted laser desorption/ionization conditions with post-source-decay analysis and hydrogen/deuterium exchange, J Amer Soc for Mass Spec 9:866-878 (1998).
Gruic-Sovulj I. et al., Matrix-assisted laser desorption/ionisation mass spectrometry of transfer ribonucleic acids isolated from yeast, Nucleic Acids Res. 25(9):1859-61 (1997).
Haglund et al., Marix-assisted laser-desorption mass spectrometry of DNA using an infrared free-electron laser, SPIE 1854:117-128.
Hsiung et al., A new simpler photoaffinity analogue of peptidyl rRNA, Nucl Acids Res 1:1753-1762 (1974).
Huth-Fehre et al., Matrix-assisted laser desorption mass spectrometry of oligodeoxythymidylic acids, Rapid Comm in Mass Spect 6:209-213 (1992).
Ji et al., Two-dimensional electrophoretic analysis of proteins expressed by normal and cancerous human crypts: Application of mass spectrometry to peptide-mass fingerprinting, Electrophoresis 15:391-405 (1994).
Juhasz et al., Applications of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry to oligonucleotide analysis, Analy Chem 68:941-946 (1996).
Jurinke et al., Analysis of ligase chain reaction products via matrix-assisted laser desorption/ionization time-of-flight-mass spectrometry, Analy Biochem 237:174-181 (1996).
Jurinke et al., Application of nested PCR and mass spectrometry for DNA-based virus detection: HBV-DNA detected in the majority of isolated anti-HBc positive sera, Genetic Analysis 14:97-102 (1998).
Jurinke et al, Detection of hepatitis B virus DNA in serum
Higgens G. Scott
Koster Hubert
Little Daniel P.
Horlick Kenneth R.
Seidman Stephanie L.
Sequenom Inc.
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