DNA detector based on molecular controlled semiconductor...

Details DNA detector based on molecular controlled semiconductor... DNA detector based on molecular controlled semiconductor...

2006-10-10

2006-10-10

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C436S094000, C257S040000

Reexamination Certificate

active

07118861

ABSTRACT:
A semiconductor device for the detection of a target DNA or RNA is provided, composed of: at least one insulating or semi-insulating layer; one conducting semiconductor layer; two conducting pads on the upper layer making electrical contact with the conducting semiconductor layer, such that electrical current can flow between them at a finite distance from the surface of the device; and a layer of at least one single-stranded DNA probe directly adsorbed on the surface of the upper layer which is either a conducting semiconductor layer or an insulating or semi-insulating layer. The DNA probe may have a sequence complementary to a sequence of the target DNA or RNA, e.g., a sequence of a gene responsible for a genetic disease or disorder, and the detection of the target DNA is carried out by hybridization with the probe and monitoring either the current change resulting from the hybridization process when a constant electric potential is applied between the two conducting pads or measuring the change in the electric potential required to keep a constant current.

REFERENCES:
patent: 4238757 (1980-12-01), Schenck
patent: 5556529 (1996-09-01), Nemoto
patent: 5632957 (1997-05-01), Heller et al.
patent: 5776672 (1998-07-01), Hashimoto et al.
patent: 5837832 (1998-11-01), Chee et al.
patent: 5945832 (1999-08-01), Harvey et al.
patent: 6251685 (2001-06-01), Dorsel et al.
patent: WO 98/19151 (1998-05-01), None
patent: WO 9819151 (1998-05-01), None
K. Gartsman et al., “Molecular Control of a GaAs Transistor”,Chemical Physics Letters, Feb. 13, 1998, vol. 238, pp. 301-306.
A. Vilan et al., “Real-Time Electronic Monitoring of Adsorption Kinetics: Evidence for Two-Site Adsorption Mechanism of Dicarboxylic Acids on GaAs(100)”,The Journal of Physical Chemistry B, Apr. 30, 1998, vol. 102, No. 18, pp. 3307-3309.

Affiliated with

Also associated with

Rating

DNA detector based on molecular controlled semiconductor... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA detector based on molecular controlled semiconductor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA detector based on molecular controlled semiconductor... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3697546