Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2003-04-21
2009-02-17
O'Hara, Eileen B (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S327000, C530S388150
Reexamination Certificate
active
07491804
ABSTRACT:
The identification and use of two major DNA-PKcs autophosphorylation sites. Threonine (T) 2609 and Serine (S) 2056, including antibodies specific for phosphorylated T2609 and 52056. Peptides and polynucleotides encoding same, that feature these two sites of phosphorylation. The antibodies do not bind to the unphosphorylated DNA-PKcs protein or peptide, thus providing diagnostic tools to monitor the effectiveness of treatments which target the DNA repair pathway of cancer cells, and the ability to intervene or inhibit in phosphorylation of T2609 or 52056, either through application of a drug or an antibody, to increase the radiosensitivity of cancer cells.
REFERENCES:
patent: 4474982 (1984-10-01), Howells
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Labvision, DNA-PKcs Ab-1 datasheet, 2002.
Chan et al. Genes and Development, vol. 16, p. 2333-2338, 2002.
Yoshihiko, et al. “Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinase”,Nucl. Acids Res., vol. 31, No. 20 (2003), pp. 5848-5857.
Autophosphoylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks, Chan, et al. (2002).
Cell Cycle Dependence of DNA-dependent Protein Kinase Phosphorylation in Response to DNA Double Strand Breaks, Chen, et al. (2005).
Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for efficient End Processing during DNA Double-Strand Break Repair, Ding, et al. (2003).
Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein, Yoo, et al. (1999).
A DNA-Activated Protein Kinase from HeLa ell Nuclei, Carter, et all (1990).
A method to detect particle-specific antibodies against Ku and the DNA-dependent protein kinase catalytic subunit in autoimmune sera, Jafri, et al. (2001).
Chan Doug W.
Chen David J.
Chen Ping-Chi Benjamin
Fulbright & Jaworski L.L.P.
Kim Yunsoo
O'Hara Eileen B
The Regents of the University of California
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