Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2006-08-29
2006-08-29
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S015000, C435S006120, C435S007100, C435S007210, C435S007230
Reexamination Certificate
active
07098012
ABSTRACT:
The present invention relates to a DNA demethylase enzyme having about 40 KDa, and wherein said DNA demethylase enzyme is overexpressed in cancer cells and not in normal cells. The present invention also relates to the therapeutic and diagnostic uses of the DNA demethylase.
REFERENCES:
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Weatherall D. J. et al. Inherited haemoglobin disorders: an increased global health problem, Bull. World Health Org. 2001, 78, 704.
Hendrich B. et al. Identification and characterization of a family of mammalian methyl-CpG binding proteins, Mol. Cell. Bioll. 1998, 18, 6548-6547.
Database GeneBank Accession No. AF72242, Oct. 28, 1998.
Lewis J. D. et al. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA, Cell, 1992, 69, 905-914.
Szyf M. et al. Ras induces a general DNA demethylation activity in mouse embrional P19 cells, J. Biol. Chem. 1995, 270, 12690-12696.
Bhattacharya Sanjoy
Ramchandani Shyam
Szyf Moshe
Crowell & Moring LLP
McGill University
Prouty Rebecca E.
Walicka Malgorzata A.
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