DNA constructs containing a Kluyveromyces alpha factor leader se

Details DNA constructs containing a Kluyveromyces alpha factor leader se DNA constructs containing a Kluyveromyces alpha factor leader se

1987-07-28

1991-04-23

Teskin, Robin L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4351723, 435255, 435256, 435320, 935 1, 935 28, 935 37, 935 48, 935 69, C07H 1512, C12P 2100, C12N 1500

Patent

active

050101820

ABSTRACT:
DNA constructs that are useful for providing secretory expression of heterologous polypeptides in yeast comprising a DNA sequence that includes a Kluyveromyces .alpha.-factor leader sequence linked to the heterologous polypeptide by a yeast processing signal. Constructs employing the K. lactis .alpha.-factor leader and processing signal sequences, with and without spacer, linked to prochymosin are exemplified.

REFERENCES:
Fujimura, et al. Arch. Microbiol. 132: 225-229, 1982.
Egel-Mitani Abstract Accession # YOO385 (England) 1987 p. 6303.
Das. J. Bacti 158(3): 1165-1167, 1984.
Rieger, et al., Glossary of Genetics New York: Springer-Vrelag 1976 p. 510.
Sakurai FEBS 203(2); 285-288, 1986.
Yanagishima Arch. Microbiol. 129:281-284, 1981.
Mas, J. et al. J. Gen. Microbiol. 121:433-440, 1980.

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