DNA-construct for the tissue-specific expression of a blood...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C424S093210, C435S069100, C435S252300, C435S440000, C514S04400A, C514S802000, C514S834000

Reexamination Certificate

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06884616

ABSTRACT:
A DNA-construct has been disclosed which is suitable for a tissue-specific expression of a blood coagulation factor like Factor IX, which comprises a DNA coding for an amino acid sequence of a blood coagulation factor and a DNA coding for a promoter which is specific for the expression in hematopoietic cells.

REFERENCES:
patent: 5565358 (1996-10-01), Marguerie de Rotrou et al.
patent: 6066778 (2000-05-01), Ginsburg et al.
patent: WO 9300438 (1993-01-01), None
patent: WO 9429471 (1994-12-01), None
patent: WO 9855639 (1998-12-01), None
Romp et al. Platelets contain releasable coagulatin factor IX antigen. (1993) Blood Coagulatoin and Fibrinolysis, vol. 4, pp. 90 910.*
Wang et al. Persistent Systemic Production of Factor IX in Mice by Skeletal Myoblast-Mediated Gene Transfer: Feasability of Repeat Application to Obtain Therapeutic Levels. (1997) Blood vol. 90, No. 3, pp. 1075-1082.*
Anderson. Human Gene Therapy. (1998) Nature vol. 392 (6679 Suppl.) pp. 25-30.*
Somia and Verma. Gene Therapy: Trials and Tribulations. (2000) Nature Reviews/Genetics, vol. 1, pp. 91-99.*
Verma and Somia. Gene therapy-promises, problems, and prospects. 1997, Nature, vol. 389, pp. 239-242.*
Uzan et al. Tissue Specific Expression of the Platelet GPllb Gene, 1991, J. Biol. Chem. vol. 266, No. 14, pp. 8932-8939.*
Hao et al. Expression of Biologically Active Human Factor IX in Human Hematopoietic Cells after Retroviral Vector-Mediated Gene transduction, 1995, Human Gene Therapy, vol. 6, pp. 873-880.*
Jallat, Sophie et al., “Characterization of Recombinant Human Factor IX Expressed in Transgenic Mice and in Derived Trans-Immortalized Hepatic Cell Lines,” The EMBO Journal, vol. 9, No. 10, pp. 3295-3301, (1990).
Kurachi, Sumiko et al., “Role of Intron I in Expression of the Human Factor IX Gene,” Journal of Biological Chemistry, vol. 270, No. 10, pp. 5276-5281, (Mar. 10, 1995).
Rodriguez, H., Abstract—XP-000938902—“Tissue Specific Expression of Factor IX in HEL Cells,” Blood, vol. 94., No. 10 (Nov. 15, 1999).
Uzan, Georges et al., “Regulation of Gene Transcription During the Differentiation of Megakaryocytes”, Thrombosis and Haemostasis, vol. 74, pp. 210-212 (1995).
Kurachi, Kotoku et al., “Regulatory Mechanism of the Factor IX Gene”, Thrombosis and Haemostasis, vol. 73, pp. 333-339 (1995).
Salier, Jean-Phillippe et al., “Functional Characterization of the 5′-Regulatory Region of Human Factor IX Gene”, The Journal of Biological Chemistry, vol. 265, No. 12, pp. 7062-7068 (Apr. 25, 1990).
Camerino, G. et al., “Regional Localization on the Human X Chromosome and Polymorphism of the Coagulation Factor IX Gene (Hemophilia B Locus)”, Proc. Natl. Acad. Sci., vol. 81, pp. 498-502 (Jan. 1984).
Yoshitake, Shinji et al., “Nucleotide Sequence of the Gene for Human Factor IX (Antihemophilic Factor B)”, Biochemistry, vol. 24, pp. 3736-3750 (1985).
Boyd, Y. et al., “Assignment of the Haemophilia B (Factor IX) Locus to the q26-qter Region of the X Chromosome”, Ann. Hum. Genet., vol. 48, pp. 145-152 (1984).
Roberts, Harold R., “Molecular Biology of Hemophila B”, Thrombosis and Haemostasis, vol. 70, pp. 1-9 (1993).
Nakai, Hiroyuki et al., “Adeno-Associated Viral Vector-Mediated Gene Transfer of Human Blood Coagulation Factor IX into Mouse Liver”, Blood, vol. 91, No. 12, pp. 4600-4607 (Jun. 15, 1998).
White, Steve J. et al., “Long-Term Expression of Human Clotting Factor IX From Retrovirally Transduced Primary Human Keratinocytes In Vivo”, Human Gene Therapy, vol. 9, pp. 1187-1195 (May 20, 1998).
Baru, Moshe et al., “Retroviral-Mediated in Vivo Gene Transfer into Muscle Cells and Synthesis of Human Factor IX in Mice”, Intervirology, vol. 38, pp. 356-360 (1995).
Wang, Jian-Min et al., “Persistent Systemic Production of Human Factor IX in Mice by Skeletal Myoblast-Mediated Gene Transfer: Feasibility of Repeat Application to Obtain Therapeutic Levels”, Blood, vol. 90, No. 3, pp. 1075-1082 (Aug. 1, 1997).
Cherington, Van et al., “Retroviral Vector-Modified Bone Marrow Stromal Cells Secrete Biologically Active Factor IX in Vitro and Transiently Deliver Therapeutic Levels of Human Factor IX ato the Plasma of Dogs After Reinfusion”, Human Gene Therapy, vol. 9, pp. 1397-1407 (Jul. 1, 1998).
Hao, Qian-Lin et al., “Expression of Biologically Active Human Factor IX in Human Hematopoietic Cells After Retroviral Vector-Mediated Gene Transduction”, Human Gene Therapy, vol. 6, pp. 873-880 (Jul. 1995).
Martin, Paul et al., “HEL Cells: A New Human Erythroleukemia Cell Line With Spontaneous and Induced Globin Expression”, Science, vol. 216, pp. 1233-1235 (Jun. 1982).
Tabilio, A. et al., “Expression of Platelet Membrane Glycoproteins and α-Granule Proteins by a Human Erythroleukemia Cell Line (HEL)”. EMBO J. vol. 3, pp. 453-459 (1984).
Long, Michael W. et al., “Regualtion of Megakaryocyte Phenotype in Human Erythroleukemia Cells”, Clinical Investigation, vol. 85, pp. 1072-1084 (Apr. 1990).
Nishizuka, Yasutomi, “The Roll of Protein Kinase C in Cell Surface Signal Transduction and Tumour Promotion”, Nature, vol. 308, pp. 693-698 (Apr. 19, 1984).
Hong, Ying et al., “Inhibition of Protein Kinase C Suppresses Megakaryocytic Differentiation and Stimulates Erythroid Differentiation in HEL Cells”, Blood, vol. 87, No. 1, pp. 123-131 (Jan. 1, 1996).
Haas, Thomas A. et al., “Integrin-Ligand Interactions: A Year in Review”, Current Opinion in Cell Biology, vol. 6, pp. 656-662 (1994).
Uzan, Georges et al., “cDNA Clones for Human Platelet GPllb Corresponding to mRNA From Megakaryocytes and HEL Cells”, Eur. J. Biochem., vol. 171, pp. 87-93 (1988).
Frachet, Philippe et al., “GPllb and GPllla Amino Acid Sequences Deduced From Human Megakaryocyte cDNAs”, Molecular Biology Reports, vol. 14, pp. 27-33 (1990).
Prandini, M.H. et al., “Isolation of the Human Platelet Glycoprotein llb Gene And Characterization of the 5′ Flanking Region”, Biochemical and Biophysical Research Communications, vol. 156, No. 1, pp. 595-601 (Oct. 14, 1988).
Bray, Paul F. et al., “Platelet Glycoprotein llb”, J. Clin. Invest., vol. 80, pp. 1812-1817 (Dec. 1987).
Uzan, Georges et al., “Tissue-Specific Expression of the Platelet GPllb Gene”, The Journal of Biological Chemistry, vol. 266, No. 14, pp. 8932-8939 (May 15, 1991).

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