DNA composition encoding an immunogenic VEGF receptor...

Details DNA composition encoding an immunogenic VEGF receptor... DNA composition encoding an immunogenic VEGF receptor...

2006-08-21

2011-11-01

Burkhart, Michael (Department: 1633)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

C424S185100, C424S093200, C424S093400, C435S252300

Reexamination Certificate

active

08048428

ABSTRACT:
A DNA composition effective for inhibiting endothelial cell proliferation comprises a DNA construct operably encoding a vascular endothelial growth factor (VEGF) receptor polypeptide, which can be a full length VEGF receptor protein or an immunogenic fragment thereof. This invention provides DNA compositions that encode VEGF receptor-2 (KDR), VEGF receptor-1 (Flt-1), or Flk-1 (the murine homolog of KDR), as well as methods of using such a DNA composition to inhibit vascular endothelial cell proliferation in the tumor micro-environment. Angiogenesis inhibition and subsequent decrease in tumor growth and dissemination is achieved.

REFERENCES:
patent: 2007/0059323 (2007-03-01), Reisfeld et al.
patent: WO 99/45018 (1999-09-01), None
Kuo, C.J. et al., “Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer”, Apr. 2001 (online Mar. 27, 2001), PNAS, vol. 98: pp. 4605-4610.

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