Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-03-10
1997-11-04
Feisee, Lila
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
5303871, 5303883, 435339, 4353201, C12N 1513, C12N 512, C07H 2104, C07K 1608
Patent
active
056841469
ABSTRACT:
An isolated DNA is provided coding for the variable region of an anti-human influenza A type virus antibody having the following characteristics: (a) specifically binds to the stem region of haemaggulutinin molecule of H1N1 and H2N2 subtypes of human influenza A type virus but does not specifically bind to the stem region of haemaggulutinin molecule of H3N2 subtype; and (b) has a neutralization activity for the H1N1 and H2N2 subtypes of human influenza A type virus but no neutralization activity for the H3N2 subtype.
REFERENCES:
patent: 5318897 (1994-06-01), Paul
Morrison, Ann Rev. Immunol. 10:239-65, 1992.
Wiley et al., "The Structure and Function of the Hemagglutinin Membrane Glycoprotein of Influenza Virus", Ann. Rev. Biochem. 1987, 56: pp. 365-394.
Green et al., "Immunogenic Structure of the Influenza Virus Hemagglutinin", Cell, vol. 28, pp. 477-487, Mar. 1982.
Shaw et al., "Characterization for A Mouse/Human Chimeric Monoclonal Antibody (17-1A) to A Colon Cancer Tumor-Associated Antigen.sup.1 ", The Journal of Immunology, vol., 138, pp. 4534-4538, No. 12 Jun. 15, 1987.
Morrison et al., "Chimeric Human Antibody Molecules: Mouse Antigen-Binding Domains with Human Constant Region Domains", Proc. Natl. Acad. Sci USA, vol. 81, pp. 6851-6855, Nov. 1984.
Inventor's speech (abstract) made at the 1st China-Japan International Congress of Virology. May 26-28, 1992. Copies of Tables 1-2, FIGS. 1-3 used in the speech are also enclosed.
Okuno et al., "A Common Neutralizing Epitope Conserved between the Hemagglutinins of Influenza A Virus H1 and H2 Strains", Journal of Virology, May 1993,pp. 2552-2558.
S. Clarke et al., "The Balb/c Secondary Response to the Sb Site of Influenza Virus Hemagglutinin", The Journal of Immunology, vol. 145, No. 7, pp. 2286-2296, Oct. 1, 1990.
Kato Ikunoshin
Okuno Yoshinobu
Oshima Atsushi
Takabatake Takashi
Yoshioka Hirofumi
Feisee Lila
Johnson Nancy A.
Takara Shuzo Co. Ltd.
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