Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Reexamination Certificate
2011-08-30
2011-08-30
Long, Scott (Department: 1633)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
C536S063000, C536S063000, C530S300000, C435S320100, C435S243000, C435S183000
Reexamination Certificate
active
08008049
ABSTRACT:
The present invention provides polypeptides that participate in the biosynthesis of the pladienolide macrolide compounds, DNA that encodes these polypeptides and variants of this DNA, transformants that maintain all or a portion of this DNA or variant thereof, and a method of producing the pladienolide macrolide compounds using these transformants. More particularly, it provides an isolated pure DNA that contains at least one region encoding a polypeptide that participates in pladienolide biosynthesis; polypeptide encoded by this DNA; a self-replicating or integrated-replicating recombinant plasmid carrying this DNA; a transformant maintaining this DNA; and a method of producing a pladienolide, characterized by culturing this transformant on culture medium and collecting pladienolide from this culture medium.
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Arisawa Akira
Machida Kazuhiro
Takeda Susumu
Tsuchida Toshio
Yoshida Masashi
Birch & Stewart Kolasch & Birch, LLP
EISAI R&D Management Co., Ltd.
Long Scott
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