DNA coding for mammalian L-asparaginase

Details DNA coding for mammalian L-asparaginase DNA coding for mammalian L-asparaginase

1998-01-16

2000-07-11

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352523, 43525233, 4353201, 536 232, 536 235, C07H 2104, C12N 982, C12N 120

Patent

active

060871512

ABSTRACT:
Disclosed is a DNA coding for mammalian L-asparaginase. Transformants introduced with the DNA effectively produce desired amounts of mammalian L-asparaginase such as those from humans, guinea pigs, and mice. The DNA is also useful as a probe for screening a DNA coding for desired mammalian L-asparaginase.

REFERENCES:
"Modified asparaginase free form antigenic activity", Chemical Abstracts, vol. 92, No. 9, 92:71908n, p. 274 (Mar. 3, 1980).
Derst et al. "Probing the role of threonine and serine residues of E. coli asparaginase II by site directed mutagensis" Prot. Engin. 5, 785-789 (1992).
Jennings et al. "Analysis of Escherichia coli gene encoding L-asparaginase II, ansB, and its . . . " J. Bacteriol. 172, 1491-1498 (Mar. 1990).
Kim et al. "Asparaginase II of Saccharomyces cerevisiae" J. Biol. Chem 263, 11948-11953 (Aug. 25, 1988).
Sun et al. "Cloning, nucleotide sequence and expression of the Bacillus subtilis ans operon, . . . " J. Bacteriol. 173, 3831-3845 (Jun. 1991).
Jerlstrom et al., "Structure and Expression in E. coli K-12 of the L-Asparaginase I-Encoding ansA Gene and its Flanking Regions," Gene, vol. 78 pp. 37-46, (1989).
Bonthron, D.T., "L-Asparaginase IIof E. coli. K-12: Cloning, Mapping and Sequencing of the ansB Gene," Gene, vol. 91, pp. 101-105, (1990).
Yellin et al., "Purification and Properties of Guinea Pig Serum Asparaginase," Biochemistry, vol. 5, No. 5, pp. 1605-1612, (1966).
Kidd, John G., "Regression of transplanted lympphomas induced in vivo by means of normal guinea pig serum." The Journal of Experimental Medicine, vol. 98, pp. 565-583 (1953).
Sambrook, J. et al., "Molecular Cloning, A Laboratory Manual." 2nd Edition, pp. xi-xxxviii (1989).
Gherna, R. et al., Catalog of Bacteria and Phages, Eighteenth Edition, No. 53323, p. 143 (1992).
Maglott, D.R. et al., Catalogue of Recombinant DNA Materials, 2nd Edition, No. 37254, p. 46 (1991).

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