DNA coding for enzyme capable of acylating the 4"-position of ma

Details DNA coding for enzyme capable of acylating the 4"-position of ma DNA coding for enzyme capable of acylating the 4"-position of ma

1989-05-23

1993-08-31

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

43525235, 4353201, 336 232, 935 11, 935 29, 935 73, 935 75, C12N 1531, C12N 1576, C12N 1570

Patent

active

052408493

ABSTRACT:
A DNA fragment containing acyB gene coding for an enzyme capable of acylating the 4"-position of a macrolide antibiotic, said DNA fragment being derived from a microorganism of the genus Streptomyces, having a size of about 3.1 kb and being characterized by the restriction endonuclease map shown in FIG. 1 , and a DNA restriction fragment resulting from digestion with a restriction endonuclease; a recombinant DNA plasmid containing this DNA fragment; a microorganism transformed with this recombinant plasmid; and a process for producing a 4"-acylated macrolide antibiotic by using the transformant.

REFERENCES:
patent: 4201843 (1980-05-01), Okamoto et al.
patent: 5068189 (1991-11-01), Epp et al.
patent: 5098837 (1992-03-01), Beckmann et al.
"Chem. Abst.", 103:32971 (Aug., 1985).
Epp et al., "Biol. Actinomycetes '88", 82-85 (1988).
"J. Antibiotics", vol. XXXIII (11), 1309-1315 (Nov., 1980).
Epp et al., "Gene", 85(2) 293-301 (Dec., 1989).
Omura et al., "J. Antibiotics", 28 401-433 (1975).
Okamoto et al., "J. Antibiotics", 32 542-544 (1979).
Epp et al., "Gene", 53 73-83 (1987).
Epp et al., "Abstracts of the Seventh International Symposium on Biology of Actinomycetes", S1b-2, 1988, Tokyo, Japan.

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