Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
1999-10-29
2002-05-28
Salimi, Ali R. (Department: 1648)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069100, C435S252300, C435S320100, C530S350000, C530S403000, C536S023720
Reexamination Certificate
active
06395512
ABSTRACT:
TABLE OF CONTENTS
I. FIELD OF THE INVENTION
II. BACKGROUND OF THE INVENTION
III. SUMMARY OF THE INVENTION
IV. BRIEF DESCRIPTION OF THE DRAWINGS
VI. EXAMPLES
A. Example 1: Identification of papilloma virus genome VS93-1G
B. Example 2: Cloning of the papilloma virus genome VS93-1-G
In the claims
Abstract of the Disclosure
I. FIELD OF THE INVENTION
The present invention relates to a DNA encoding a peptide of a papilloma virus major capsid protein. Furthermore, this invention concerns a papilloma virus genome containing such a DNA. In addition, this invention relates to proteins encoded by the papilloma virus genome and to virus-like particles as well as antibodies directed thereagainst and the use thereof in diagnosis, treatment and vaccination.
II. BACKGROUND OF THE INVENTION
It is well known that papilloma viruses infect the epithelial tissue of humans and animals. Human papilloma viruses (referred to as HP viruses below) are found in benign, e.g., warts, condylomata in the genital region, and malign, e.g., carcinomas of the skin and uterus, epithelial neoplasms. Zur Hausen, 1989,
Cancer Research
49:4677-4681. HP viruses are also considered for the development of malign tumors of the respiratory tract. Zur Hausen, 1976,
Cancer Research
36:530. In addition, HP viruses are considered at least co-responsible for the development of squamous carcinomas of the lungs. Syrjänen, 1980,
Lung
158:131-142.
Papilloma viruses have an icosahedral capsid without coat, which includes a circular, double-stranded DNA molecule of about 7,900 bp. The capsid comprises a major capsid protein (L1) and a minor capsid protein (L2). Both proteins, coexpressed or L1 expressed alone, result in vitro to the development of virus-like particles. Kirnbauer et al., 1993,
Journal of Virology
67:6929-6936.
Papilloma viruses cannot be proliferated in monolayer cell culture. Therefore, their characterization is extremely difficult, the detection of papilloma viruses already creating considerable problems. This applies particularly to papilloma viruses in carcinomas of the skin. A reliable detection thereof and thus well-calculated steps thereagainst have not been possible by now.
Therefore, it is the object of the present invention to provide an agent serving for detecting papilloma viruses, particularly in carcinomas of the skin. Furthermore, an agent is to be provided which serves for taking therapeutic steps against these papilloma viruses.
According to the inventions this is achieved by the provision of the subject matters in the claims.
III. SUMMARY OF THE INVENTION
The present invention is directed to a DNA encoding a peptide of a papilloma virus major capsid protein.
The present invention is also directed to a papilloma virus genome containing such a DNA.
The present invention is further directed to proteins encoded by the papilloma virus genome and to virus-like particles as well as antibodies directed thereagainst and the use thereof in diagnosis, treatment and vaccination.
REFERENCES:
patent: WO A91 18294 (1991-02-01), None
patent: WO A93 02184 (1993-05-01), None
patent: WO A94 00152 (1994-01-01), None
patent: WO A94 05792 (1994-03-01), None
patent: WO A94 20137 (1994-09-01), None
Volpers et al. Virology, vol. 181, pp. 419-423, 1991.*
Shamanin, et al., Sep. 1994, “Specific types of human papillomavirus found in benign proliferations and carcinomas of the skin in immunosuppressed patients”,Cancer Research 17:4610-4613.
zur Hausen, 1989,Cancer Research 49:4677-4681.
zur Hausen, 1976,Cancer Research 36:530.
Syrjänen, 1980,Lung 158:131-142.
Kirnbaur, et al., 1993,J. Virology6929-6936.
Hagensee, et al., 1993,J. Virology315-322.
Rose et al., 1993, J. of Virology, vol. 67(4), pp. 1936-1944.
Tomita et al., 1987, J. of Virology, vol. 61(8), pp. 2389-2394.
Tomita et al., 1987, J. of Virology, vol. 158, pp. 8-14.
De Villiers-Zur Hausen Ethel-Michele
Hausen Harald Zur
Leigh Irene
Shamanin Vladimir
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Recht
Pennie & Edmonds LLP
Salimi Ali R.
LandOfFree
DNA coding for a peptide of a papilloma virus main capside... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA coding for a peptide of a papilloma virus main capside..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA coding for a peptide of a papilloma virus main capside... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2825554