DNA coding for a human vasoconstrictive peptide and use thereof

Details DNA coding for a human vasoconstrictive peptide and use thereof DNA coding for a human vasoconstrictive peptide and use thereof

1996-06-28

1998-05-26

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 694, 435325, 43525233, 4353201, 530324, 530315, 536 2351, C07K 14575, C12N 1516, C12N 121

Patent

active

057563446

ABSTRACT:
Disclosed are (1) a DNA containing a cDNA segment coding for human endothelin-2 (SEQ ID NO:1), (2) a precursor of human endothelin-2 (SEQ ID NO:2), (3) a transformant carrying a DNA containing a cDNA segment coding for human endothelin-2, and (4) a method for preparing mature human endothelin-2 which comprises culturing the transformant described in (3), accumulating a protein in a culture medium, and collecting the same, whereby human endothelin-2 and the precursors thereof can be produced in large amounts.

REFERENCES:
Yangisawa et al., "The Human Endothelin Family: cDNA Cloning, Complete Primary Structure and Differential Tissue Expression of the Three Precursors", European Journal of Pharmacology, 183(5), 1628-1629, Jul. 1990.
Yangisawa et al., "cDna Cloning and Differential Tissue Expression of Human Endothelin-2 and Endothelin-3", Japanese Journal of Pharmacology, 52, Supplement I 112P, Abstract 0-123, Mar. 1990.
Berger et al. (editors), Guide to Molecular Cloning Techniques, Methods in Enzymology, 152: 393-399, 415-423, 433-447, 661-704, 1987.
Berger, et al. (editors), Guide to Molecular Cloning Techniques, Methods in Enzymology, vol. 152, pp. 393-399, 415-423, 433-447 and 661-704, 1987.
Yangisawa et al., "cDNA Cloning and Differential Tissue Expression of Human Endothelin-2 and Endothelin-3", Japanese Journal of Pharmacology, vol. 52, Supplement I, p. 112P, Abstract 0-123, Mar. 1990.
Yangisawa et al., "The Human Endothelin Family: cDNA Cloning, Complete Primary Structure and Differential Tissue Expression of the Three Precursors", European Journal of Pharmacology, vol. 183(5), pp. 1628-1629, Jul. 1990.
Inoue et al., "The Human Endothelin Family: Three Structurally and Pharmacologically Distinct Isopeptides Predicted By Three Separate Genes", Proc. Natl. Acad. Sci., vol. 86, pp. 2863-2867, Apr. 1989.
S. Ohkubo, et al. FEBS Letters, Vo. 274, No. 1-2, Nov. 12, 1990, Amsterdam NL pp. 136-140.
Y. Itoh, et al., FEBS Letters, 231:440-444. (1988).
K.D. Bloch, et al. Genomics, vol. 10, No. 1, May 1991, San Diego, US pp. 236-242.

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