DNA cloning and expression of an L7 protein which modulates the

Details DNA cloning and expression of an L7 protein which modulates the DNA cloning and expression of an L7 protein which modulates the

1993-09-13

1994-10-25

Lacey, David L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4353201, 435 6952, 530351, 424 854, 536 2352, A61K 3766, C12P 2106, C12N 1500, C07H 1700

Patent

active

053588673

ABSTRACT:
The gene encoding a protein (L7) which appears to be a part of the human Type I interferon receptor has been cloned and expressed by recombinant DNA techniques. The protein imparts a non-species specific enhanced responsiveness to Type I interferon to transformed cells. The protein is found on the surface of Daudi cells and has structural features characteristic of receptor proteins.

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Yonehara, S. et al., "Monoclonal Anti-Idiotype Antibody for Anti-Human Interferon-.alpha. that Compete with Interferon-.alpha. in Binding to Human Cell Surface and Inhibit the Interferon Action," in The Biology of the Interferon System 1985: Proceedings of the 1985 TNO-ISIR Meeting on the Interferon System, Held in Clearwater Beach, Florida, USA on 13-18 Oct., 1985, Steward, W. E. et al., Eds., Elsevier Science, Amsterdam, 1986.
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