DNA clone of human thrombomodulin and portions thereof

Details DNA clone of human thrombomodulin and portions thereof DNA clone of human thrombomodulin and portions thereof

1987-05-06

1990-03-27

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 2100, C07H 2104

Patent

active

049122070

ABSTRACT:
A cDNA having a base sequence for human thrombomodulin has been cloned and characterized and the amino acid sequence of the human thrombomodulin has been determined.

REFERENCES:
Esmon et al., J. Biol. Chem. 257, 859-864 (1982).
Suzuki et al., Biochim. Biophys. Acta 882, 343-352 (1986).
Jakubowski et al., J. Biol. Chem. 261, 3876-3882 (1986).
Maruyama et al., J. Clin. Invest. 75, 987-991 (1985).
Salem et al., J. Biol. Chem. 259, 12246-12451 (1984).
Maruyama et al., J. Cell. Biol. 101, 363-371 (1985).
Jackman et al., Proc. Natl. Acad. Sci. USA, 83, 8834-8838 (1986).
Maruyama and Majerus, J. Biol. Chem. 260, 15432-15438 (1985).
Bourin et al., Proc. Natl. Acad. Sci. USA 83, 5924-5928 (1986).
Freyssinet et al., Thromb. Haemost. 55, 112-118 (1986).
Esmon, Science 235, 1348-1352 (1987).
Suzuki et al., EMBo Journal, vol. 6, pp. 1891-1897, 1987.

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