DNA cassette and transgenic organisms carrying lytic peptide-enc

Details DNA cassette and transgenic organisms carrying lytic peptide-enc DNA cassette and transgenic organisms carrying lytic peptide-enc

1993-08-30

1996-08-20

Fleisher, Mindy

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 234, 536 241, 536 2431, C12N 1511, C12N 1512, C12N 1562

Patent

active

055480756

ABSTRACT:
A DNA cassette containing sequences encoding a lytic peptide under the transcriptional control of an immune system regulating sequence is disclosed. The control sequences normally permit expression only when a defined indicator(s) reflective of a disease state is present, and tightly inhibit expression when such indicator(s) is absent. The invention further extends to transgenic unicellular and multicellular organisms having the cassette stably integrated in their genetic material. A preferred embodiment of the cassette has the Shiva-1 lytic peptide under the control of IL-2 (interleukin-2) regulating sequences. In a preferred embodiment of multicellular organisms, the cassette is incorporated into the genomes of the germ cells and the organisms are capable of transmitting it to their offspring.

REFERENCES:
patent: 4952499 (1990-08-01), Cantor
patent: 4992367 (1991-02-01), Cullen
Nagpala et al. (1990), J. Cell Biochem., Supplement 14 part E, p. 323, abstract R330.
Novak et al. (1990), Nucl. Acids Res. 18(15):4523-4533.
J. Jaynes et al., "In vitro Cytocidal Effect of Lytic Petides on Several Transformed Mamnalian Cell Lines," Peptide Research, pp. 157-160.
W. Reed et al., "Enhanced In Vitro Growth of Murine Fibroblast Cells and Preimplantation Embryos Cultured in Medium Supplemented with an Amphipathic Peptide," Mol Reprod & Devel, 31:106-113 (1992).

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